Quantifying the effects of quadrupolar sinks via 15 N relaxation dynamics in metronidazoles hyperpolarized via SABRE-SHEATH.

Authors :: Birchall JR
Kabir MSH
Salnikov OG
Chukanov NV
Svyatova A
Kovtunov KV
Koptyug IV
Gelovani JG
Goodson BM
Pham W
Chekmenev EY
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2020 Aug 18; Vol. 56 (64), pp. 9098-9101. Date of Electronic Publication: 2020 Jul 14.
Publication Year :: 2020
Abstract: <superscript>15</superscript> N spin-lattice relaxation dynamics in metronidazole- <superscript>15</superscript> N <subscript>3</subscript> and metronidazole- <superscript>15</superscript> N <subscript>2</subscript> isotopologues are studied for rational design of <superscript>15</superscript> N-enriched biomolecules for signal amplification by reversible exchange in microtesla fields. <superscript>15</superscript> N relaxation dynamics mapping reveals the deleterious effects of interactions with the polarization transfer catalyst and a quadrupolar <superscript>14</superscript> N nucleus within the spin-relayed <superscript>15</superscript> N- <superscript>15</superscript> N network.

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