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Navigating small biopsies of salivary gland tumors: a pattern-based approach.
- Source :
-
Journal of the American Society of Cytopathology [J Am Soc Cytopathol] 2020 Sep - Oct; Vol. 9 (5), pp. 369-382. Date of Electronic Publication: 2020 Jun 19. - Publication Year :
- 2020
-
Abstract
- Diagnosis of salivary gland tumors on small biopsy can be difficult because of overlapping morphology, limited tissue availability, and technical artifact. Although a specific diagnosis is not feasible in all cases, a cautious and thoughtful approach to the differential diagnosis and a keen awareness of clinical consequences can facilitate the most complete and useful classification possible. In this review, we present a general strategy for the evaluation of small salivary biopsies, including consideration of clinical and radiographic information, systematic assessment of histologic patterns, and judicious use of immunohistochemistry and molecular studies. We then focus on the distinctive differential diagnoses raised by 6 specific histologic patterns: tubular and cribriform architecture, squamous differentiation, mucin and other secretions, high-grade cytology, epithelial and lymphoid elements, and oncocytic features. Throughout this systematic and pattern-based approach, we focus on practical and cost-effective strategies to overcome the most common diagnostic challenges in limited material.<br /> (Copyright © 2020 American Society of Cytopathology. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Artifacts
Biomarkers, Tumor metabolism
Biopsy methods
Carcinoma, Adenoid Cystic metabolism
Carcinoma, Adenoid Cystic pathology
Carcinoma, Mucoepidermoid metabolism
Carcinoma, Mucoepidermoid pathology
Carcinoma, Squamous Cell metabolism
Carcinoma, Squamous Cell pathology
Diagnosis, Differential
Humans
Immunohistochemistry methods
Mucins biosynthesis
Salivary Gland Neoplasms metabolism
Salivary Gland Neoplasms pathology
Carcinoma, Adenoid Cystic diagnosis
Carcinoma, Mucoepidermoid diagnosis
Carcinoma, Squamous Cell diagnosis
Salivary Gland Neoplasms diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 2213-2945
- Volume :
- 9
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of the American Society of Cytopathology
- Publication Type :
- Academic Journal
- Accession number :
- 32660844
- Full Text :
- https://doi.org/10.1016/j.jasc.2020.06.004