Comparison of whole-cell versus acellular pertussis vaccine effectiveness in school clusters of pertussis, France, 2013.

Authors :: Belchior E
Guillot S
Poujol I
Thabuis A
Chouin L
Martel M
Delisle E
Six C
Guiso N
Lévy-Bruhl D
Source :: Medecine et maladies infectieuses [Med Mal Infect] 2020 Oct; Vol. 50 (7), pp. 617-619. Date of Electronic Publication: 2020 Jul 10.
Publication Year :: 2020
Abstract: Objectives and Method: We conducted a prospective study in 2013 to compare the whole-cell versus acellular pertussis vaccines effectiveness and duration of protection, following the occurrence of pertussis clusters.<br />Results: During seven school outbreaks, we identified 102 clinical pertussis cases, including 10 cases biologically confirmed by Bordetella pertussis specific PCR, among a cohort of 305 children in 2nd to 6th grade. The risk of pertussis when vaccinated with an acellular vaccine alone was 1.6 (RR=1.6; 95% CI=1.1-2.5) times higher than when vaccinated with a whole-cell vaccine or using a combined schedule.<br />Conclusions: The limited duration of protection conferred by the acellular vaccine reinforces the 2013 introduction of the pertussis booster at six years old.<br /> (Copyright © 2020 Elsevier Masson SAS. All rights reserved.)

Subjects :: Child
Child, Preschool
France epidemiology
Humans
Infant
Prospective Studies
Schools
Vaccines, Acellular
Disease Outbreaks
Pertussis Vaccine immunology
Whooping Cough epidemiology
Whooping Cough prevention & control

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