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New heterocyclic ring systems--V synthesis and pharmacological activity of 6H-1,3,4-thiadiazolo [3',2':1,2]-5-oxopyrimido [5,4-b] indole derivatives and of 1-phenyl-6H-1,2,4-triazolo [1',5':1,2]-5-oxopyrimido[5,4-b] indole.
- Source :
-
Il Farmaco; edizione scientifica [Farmaco Sci] 1988 May; Vol. 43 (5), pp. 409-20. - Publication Year :
- 1988
-
Abstract
- As a part of a study on analgesic and antiinflammatory active condensed heterocyclic compounds containing the pyrimidinic ring, a number of 6H-1,3,4-thiadiazolo [3',2':1,2]-5-oxopyrimido [5,4-b]indole and 1-phenyl-6H-1,2,4-triazolo [1',5':1,2]-5-oxopyrimido [5,4-b] indole were synthesized and tested. The results of pharmacological assays are reported and discussed.
- Subjects :
- Animals
Anti-Inflammatory Agents, Non-Steroidal toxicity
Behavior, Animal drug effects
Chemical Phenomena
Chemistry
Indoles chemical synthesis
Indoles pharmacology
Indoles toxicity
Lethal Dose 50
Mice
Pyrimidines pharmacology
Pyrimidines toxicity
Rats
Stomach Ulcer chemically induced
Thiadiazoles chemical synthesis
Thiadiazoles pharmacology
Thiadiazoles toxicity
Triazoles chemical synthesis
Triazoles pharmacology
Triazoles toxicity
Anti-Inflammatory Agents, Non-Steroidal chemical synthesis
Pyrimidines chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0430-0920
- Volume :
- 43
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Il Farmaco; edizione scientifica
- Publication Type :
- Academic Journal
- Accession number :
- 3265391