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Effects of 5-Hydroxypyrimidine Derivatives on Tumor Growth and Lifespan of C57BL/6 Mice with Epidermoid Lung Carcinoma.
- Source :
-
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2020 Jun; Vol. 169 (2), pp. 262-265. Date of Electronic Publication: 2020 Jul 10. - Publication Year :
- 2020
-
Abstract
- The effects of 5-hydroxypyrimidine derivatives SNK-411 (2-isobutyl-4,6-dimethyl-5-hydroxypyrimidine) and SNK-578 (2-isobutyl-4,6-dimethyl-5-hydroxypyrimidine chlorohydrate) on the tumor growth and survival of male C57BL/6 mice with transplanted Lewis lung epidermoid carcinoma (LLC) were studied in animals receiving intraperitoneal treatment on days 2-15 of tumor development. Compound SNK-578 in a dose of 10 mg/kg significantly inhibited tumor growth (by 3.6 times; 72.2%) in 7 days after the treatment was discontinued, while compound SNK-411 in a dose of 25 mg/kg only negligibly reduced tumor volume (by 41.7%). A combination of course of SNK-411 (25 mg/kg) and single intraperitoneal dose of doxorubicin (4 mg/kg) significantly inhibited the tumor growth (by 2.2 times; 55.2%), while the combination of SNK-578 (10 mg/kg) with doxorubicin (4 mg/kg) was in fact ineffective. The median survival of animals with untreated LLC was 28 days. Median survival of mice injected with SNK-578 (10 mg/kg) was 43 days, hence, the lifespan of mice with LLC was by 38.6% longer after the treatment. Two of ten mice in this group developed no tumors.
- Subjects :
- Animals
Doxorubicin therapeutic use
Longevity drug effects
Male
Mice
Mice, Inbred C57BL
Pyrimidines therapeutic use
Tumor Burden drug effects
Antineoplastic Agents chemistry
Antineoplastic Agents therapeutic use
Carcinoma, Lewis Lung drug therapy
Lung Neoplasms drug therapy
Pyrimidines chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1573-8221
- Volume :
- 169
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Bulletin of experimental biology and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 32651822
- Full Text :
- https://doi.org/10.1007/s10517-020-04864-z