Start Over

Association of MMP2-1306C/T Polymorphism with Ischemic Retinal Vein Occlusion.

Authors :: Christodoulou A
Bagli E
Gazouli M
Moschos MM
Kitsos G
Source :: Archives of medical research [Arch Med Res] 2020 Oct; Vol. 51 (7), pp. 710-713. Date of Electronic Publication: 2020 Jul 06.
Publication Year :: 2020
Abstract: Purpose: To investigate the possible association of the matrix metalloproteinase 2 (MMP2)-1306C/T polymorphism with the risk of ischemic retinal vein occlusion (iRVO).<br />Methods: A total of 69 patients with RVO were enrolled in this study (43 with non-iRVO and 26 with iRVO). All subjects were screened for hypertension, diabetes mellitus, hyperlipidemia, history of stroke, anticoagulant medication, smoking status and glaucoma. The genotyping of MMP2-1306C/T polymorphism was performed using PCR-RFLP-based methods.<br />Results: MMP2-1306C/T T allele carriers (CT+TT) were statistically significant associated with a higher risk of iRVO compared to CC genotype in the overall RVO group (odds ratio = 3.91, p = 0.015, 95% confidence interval:1.30-11.79). Analysis, following stratification by age revealed that T allele carriers had a statistically significant increased risk of iRVO compared to C allele carriers only in RVO patients <75 years old.<br />Conclusion: Our results demonstrated that MMP2-1306C/T polymorphism is a likely predisposing factor for iRVO in patients <75 years old. This is the first study attempting association of a gene polymorphism with the prevalence of iRVO.<br /> (Copyright © 2020 IMSS. Published by Elsevier Inc. All rights reserved.)