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Fractional excretion of tumor necrosis factor receptor 1 and 2 in patients with type 2 diabetes and normal renal function.
- Source :
-
Journal of diabetes investigation [J Diabetes Investig] 2021 Mar; Vol. 12 (3), pp. 382-389. Date of Electronic Publication: 2020 Aug 10. - Publication Year :
- 2021
-
Abstract
- Aims/introduction: Increased concentrations of serum tumor necrosis factor (TNF) receptors (TNFRs; TNFR1 and TNFR2) are positively associated with the urinary albumin-to-creatinine ratio (ACR), and negatively associated with the estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes. However, the mechanism underlying this increase and the relationship between TNFRs in serum, and urine and kidney measures (ACR and eGFR) are unclear.<br />Materials and Methods: This was a cross-sectional study that included 499 patients with type 2 diabetes and eGFR ≥60 mL/min/1.73 m <superscript>2</superscript> . The concentrations of TNFRs in serum and urine, and their respective fractional excretion, were measured.<br />Results: Serum and urinary TNFR levels were positively associated with the ACR, and negatively associated with the eGFR. The fractional excretion of TNFRs did not differ between patients with an eGFR ≥90 and those with an eGFR 60-89 mL/min/1.73 m <superscript>2</superscript> , and also did not correlate with eGFR. After adjustment for relevant covariates, the serum TNFRs were associated with a lower eGFR (60-89 mL/min/1.73 m <superscript>2</superscript> ) and an increased ACR (≥30 mg/gCr), but urinary TNFRs were associated with an increased ACR (≥30 mg/gCr) alone, in the multivariate logistic model.<br />Conclusions: The pattern of fractional excretion TNFRs showed that an increase in serum TNFRs might result from their increased systemic production, including in the kidney, rather than being a simple reflection of GFR decline. Kidney measures appear to be strongly associated with serum TNFRs rather than urinary TNFRs in patients with type 2 diabetes and normal renal function.<br /> (© 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.)
- Subjects :
- Aged
Cross-Sectional Studies
Female
Glomerular Filtration Rate
Humans
Kidney physiopathology
Kidney Function Tests
Male
Middle Aged
Diabetes Mellitus, Type 2 blood
Diabetes Mellitus, Type 2 urine
Kidney metabolism
Receptors, Tumor Necrosis Factor, Type I blood
Receptors, Tumor Necrosis Factor, Type I urine
Receptors, Tumor Necrosis Factor, Type II blood
Receptors, Tumor Necrosis Factor, Type II urine
Subjects
Details
- Language :
- English
- ISSN :
- 2040-1124
- Volume :
- 12
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of diabetes investigation
- Publication Type :
- Academic Journal
- Accession number :
- 32643269
- Full Text :
- https://doi.org/10.1111/jdi.13351