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Pathological Predictors of Response to Neoadjuvant Treatment in Rectal Carcinoma.
- Source :
-
Journal of gastrointestinal cancer [J Gastrointest Cancer] 2021 Jun; Vol. 52 (2), pp. 690-695. - Publication Year :
- 2021
-
Abstract
- Purpose: Neoadjuvant chemoradiotherapy has now become a standard treatment for rectal cancer. Recently, attempts have been made to predict the response rate to this treatment to decide whether or not it must be performed. However, tissue factors for predicting the response rate is not cohesively reviewed.<br />Methods: Eighty-three patients with rectal cancer, all under neoadjuvant chemoradiotherapy and subsequent surgery, were examined for tissue factors in the biopsy sample. The tissue factors examined include tumor differentiation grade, lymphovascular invasion, perineural invasion, pathological stage, and lymphocytic infiltration. Lymphocytic infiltration was investigated by immunohistochemistry for CD8 T lymphocyte in biopsy samples.<br />Results: In this study, tissue factors were found to play a decisive role in predicting response to neoadjuvant treatment. The most important factor was the pathological stage, which has the highest correlation with response to treatment. There is a significant relationship between CD8 lymphocyte infiltration and response to treatment (P value = 0.018). Primary perineural invasion and lymphovascular invasion also have a significant meaningful relationship with response to treatment (P value = 0.021 and P value = 0.036).<br />Conclusion: In this study, it was determined that the investigated factors have a significant relationship with response to treatment and could be used to predict the response to treatment, and if a low possibility of positive response exists, prevention of the complications of neoadjuvant chemoradiotherapy for the patients could occur.
- Subjects :
- Biopsy
Capecitabine administration & dosage
Chemoradiotherapy, Adjuvant methods
Dose Fractionation, Radiation
Female
Humans
Male
Middle Aged
Neoadjuvant Therapy methods
Neoplasm Invasiveness pathology
Prognosis
Rectal Neoplasms pathology
Rectum drug effects
Rectum radiation effects
Rectum surgery
Treatment Outcome
Chemoradiotherapy, Adjuvant statistics & numerical data
Neoadjuvant Therapy statistics & numerical data
Proctectomy
Rectal Neoplasms therapy
Rectum pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1941-6636
- Volume :
- 52
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of gastrointestinal cancer
- Publication Type :
- Academic Journal
- Accession number :
- 32643115
- Full Text :
- https://doi.org/10.1007/s12029-020-00450-8