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Baricitinib as rescue therapy in a patient with COVID-19 with no complete response to sarilumab.
- Source :
-
Infection [Infection] 2020 Oct; Vol. 48 (5), pp. 767-771. Date of Electronic Publication: 2020 Jul 08. - Publication Year :
- 2020
-
Abstract
- A patient with COVID-19-related severe respiratory failure, with insufficient response to an antiretroviral therapy, hydroxychloroquine and Interleukin-6 (IL-6) antagonist therapy, presented a prompt resolution of the respiratory function and improvement in the radiological picture after baricitinib at an oral dose of 4 mg per day for 2 weeks.
- Subjects :
- Acute Disease
Aged
Antibodies, Monoclonal, Humanized therapeutic use
Azithromycin therapeutic use
Betacoronavirus drug effects
COVID-19
Coronavirus Infections physiopathology
Coronavirus Infections virology
Drug Combinations
Drug Repositioning
Humans
Hydroxychloroquine therapeutic use
Lopinavir therapeutic use
Male
Pandemics
Pneumonia, Viral physiopathology
Pneumonia, Viral virology
Purines
Pyrazoles
Respiratory Insufficiency physiopathology
Respiratory Insufficiency virology
Ritonavir therapeutic use
SARS-CoV-2
Treatment Outcome
Antiviral Agents therapeutic use
Azetidines therapeutic use
Betacoronavirus pathogenicity
Coronavirus Infections drug therapy
Pneumonia, Viral drug therapy
Respiratory Insufficiency drug therapy
Sulfonamides therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1439-0973
- Volume :
- 48
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Infection
- Publication Type :
- Academic Journal
- Accession number :
- 32642806
- Full Text :
- https://doi.org/10.1007/s15010-020-01476-7