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Comparison of the Effects of Fenugreek Vaginal Cream and Ultra Low- Dose Estrogen on Atrophic Vaginitis.
- Source :
-
Current drug delivery [Curr Drug Deliv] 2020; Vol. 17 (9), pp. 815-822. - Publication Year :
- 2020
-
Abstract
- Introduction: Atrophic vaginitis is a common problem in postmenopausal women and results from decreased levels of blood estrogen. It is associated with symptoms of itching, burning, dyspareunia, and postmenopausal bleeding. The present study evaluated the effects of fenugreek extract on atrophic vaginitis.<br />Materials and Methods: This randomized controlled clinical trial was performed on 60 postmenopausal women in Ardabil, Iran, in 2018. The participants were selected using block randomization with the allocation ratio 1:1. Those in the intervention group received 0.5g (the applicator filled to the half-full mark) fenugreek vaginal cream 5% twice a week for 12 weeks. The control group received conjugated estrogens vaginal cream at the dose of 0.625 mg (the applicator filled to the half-full mark) containing 0.3 mg of conjugated estrogens. Atrophic vaginitis was evaluated before and after the treatment through clinical examination, clinical signs, and measurement of Vaginal Maturation Index (VMI).<br />Findings: After the 12-week intervention and modification of the baseline score, the mean (standard error) score for atrophic vaginitis signs was 3.100 (1.43-4.75). This difference was statistically significant in intragroup comparison and in favor of the control group in intergroup comparison (p=0.001). VMI was less than 49% in 86.7% and 46.7% of the participants in the intervention and control groups, respectively. This was a significant difference in favor of the control group (p=0.001).<br />Conclusion: The results of this study showed that total fenugreek extract could be effective in treating signs of atrophic vaginitis, but it was not as effective as ultra-low-dose estrogen.<br /> (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
- Subjects :
- Administration, Intravaginal
Atrophic Vaginitis blood
Atrophic Vaginitis diagnosis
Atrophic Vaginitis pathology
Dose-Response Relationship, Drug
Estrogens blood
Female
Humans
Middle Aged
Postmenopause blood
Treatment Outcome
Trigonella chemistry
Vagina drug effects
Vagina pathology
Vaginal Creams, Foams, and Jellies
Atrophic Vaginitis drug therapy
Estrogens administration & dosage
Estrogens, Conjugated (USP) administration & dosage
Plant Extracts administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1875-5704
- Volume :
- 17
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Current drug delivery
- Publication Type :
- Academic Journal
- Accession number :
- 32640956
- Full Text :
- https://doi.org/10.2174/1567201817666200708112655