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Highly Modified Lanostane Triterpenes from the Wood-Rot Basidiomycete Ganoderma colossus : Comparative Chemical Investigations of Natural and Artificially Cultivated Fruiting Bodies and Mycelial Cultures.
- Source :
-
Journal of natural products [J Nat Prod] 2020 Jul 24; Vol. 83 (7), pp. 2066-2075. Date of Electronic Publication: 2020 Jul 08. - Publication Year :
- 2020
-
Abstract
- The wood-rot basidiomycete Ganoderma colossus has been chemically investigated. Comparative analyses of the natural fruiting body, artificially cultivated fruiting bodies, and mycelial cultures resulted in the isolation, in total, of 13 new highly modified lanostanes, ganocolossusins A-H ( 1 - 8 ) and ganodermalactones T-X ( 9 - 13 ), together with 23 known compounds ( 14 - 36 ). There were significant overlaps of the same compounds among the three different states of the fungal materials. Ganocolossusin D ( 4 ) displayed the most potent antimalarial activity against Plasmodium falciparum K1 (multi-drug-resistant strain) with an IC <subscript>50</subscript> value of 2.4 μM, while it was noncytotoxic to Vero cells at 50 μg/mL.
- Subjects :
- Carbon-13 Magnetic Resonance Spectroscopy
Molecular Structure
Plasmodium falciparum drug effects
Proton Magnetic Resonance Spectroscopy
Spectrometry, Mass, Electrospray Ionization
Triterpenes chemistry
Triterpenes pharmacology
Fruiting Bodies, Fungal chemistry
Mycelium chemistry
Polyporaceae chemistry
Triterpenes isolation & purification
Wood microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6025
- Volume :
- 83
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 32639735
- Full Text :
- https://doi.org/10.1021/acs.jnatprod.9b00947