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Comparison of serum NEDD-9, CA 15-3, and CEA levels and PET metabolic parameters in breast cancer patients with 18 F-FDG PET / CT.
- Source :
-
Revista da Associacao Medica Brasileira (1992) [Rev Assoc Med Bras (1992)] 2020 May; Vol. 66 (5), pp. 673-679. Date of Electronic Publication: 2020 Jul 03. - Publication Year :
- 2020
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Abstract
- OBJECTIVE Analyze the over expression of neural precursor cell expressed developmentally down-regulated protein 9 (NEDD-9) deregulated associated with a poor prognosis in various carcinomas. Our objective was to investigate the relationship between the levels of NEDD-9, CA 15-3, and CEA and PET (SUVmax, MTV40, TLG40) with the clinical parameters of patients with breast cancer (BC). METHODS One hundred and eleven patients (82 BC patients who underwent 18F-FDG PET/CT and 29 healthy controls) were evaluated. SUVmax, MTV, and TLG of the primary tumor were compared with the molecular and histopathological subtypes. 18F-FDG, MTV, and TLG were evaluated based on the clinical data, i.e., nodal involvement, distant metastasis, ER and PR status, Ki-67, serum levels of NEDD-9, CA15-3, and CEA. We compared the NEDD-9 in the BC and healthy control groups. RESULTS The mean ± SD of SUVmax in the 82 patients was 13.0 ± 8.6. A statistically significant relationship (p = 0.022) was found between the molecular subtypes and 18F-FDG uptake. The relationship between 18F-FDG uptake and TLG measured in patients <50 years, ER-PR negativity, and HER2 positivity were statistically significant (p=0.015, 0.007, 0.046, and 0.001, respectively). MTV40, TLG40, and CA 15-3 in metastatic patients were statistically significant (p=0.004, 0.005, and 0.003, respectively). NEDD-9 in the BC group was significantly higher than in the healthy group (p=0.017). There was a positive correlation between SUVmax and Ki67 and CA 15-3; MTV40 and CEA; CA 15-3, CEA, SUVmax, and MTV40; a negative correlation was found between CEA, TLG40, and age. CONCLUSION The use of SUVmax, MTV40, and TLG40 parameters with NEDD-9 and tumor markers has been shown to provide a high diagnostic, predictive, and prognostic value for the management of BC. This is considered to be the basis of interventions focused on the treatment objectives related to NEDD-9.
- Subjects :
- Carcinoembryonic Antigen blood
Fluorodeoxyglucose F18
Humans
Microtubule-Associated Proteins blood
Mucin-1 blood
Positron-Emission Tomography
Prognosis
Radiopharmaceuticals
Retrospective Studies
Tomography, X-Ray Computed
Breast Neoplasms blood
Positron Emission Tomography Computed Tomography
Subjects
Details
- Language :
- English
- ISSN :
- 1806-9282
- Volume :
- 66
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Revista da Associacao Medica Brasileira (1992)
- Publication Type :
- Academic Journal
- Accession number :
- 32638964
- Full Text :
- https://doi.org/10.1590/1806-9282.66.5.673