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Patch testing with purified and oxidized citronellol.
- Source :
-
Contact dermatitis [Contact Dermatitis] 2020 Nov; Vol. 83 (5), pp. 372-379. Date of Electronic Publication: 2020 Sep 01. - Publication Year :
- 2020
-
Abstract
- Background: Citronellol is a commonly used fragrance terpene included in fragrance mix II. As with many other fragrance terpenes, citronellol is susceptible to autoxidation. Citronellol hydroperoxides are formed in large amounts and are the only oxidation products identified as sensitizers in oxidized citronellol.<br />Aim: To compare frequencies of contact allergy to purified and oxidized citronellol and to investigate the pattern of concomitant reactions to fragrance markers of the baseline series, oxidized linalool, and oxidized limonene.<br />Methods: A total of 658 dermatitis patients were patch tested with purified and oxidized citronellol at 2.0%, 4.0%, 6.0%, and 1.0%, 2.0%, 4.0%, 6.0% petrolatum, respectively. The irritant properties of purified and oxidized citronellol were studied before patch testing.<br />Results: Few irritant reactions were observed in the pretest. Purified citronellol detected positive reactions in 0.15%-0.31% of patients, while oxidized citronellol detected positive reactions in 0.61%-4.5%. Among patients reacting to oxidized citronellol, 34%-50% showed concomitant reactions to fragrance markers of the baseline series and 75%-91% to oxidized linalool or oxidized limonene.<br />Conclusion: Oxidized citronellol detects more cases of contact allergy than purified citronellol, and these cases are not all detected using fragrance mix II. Patch testing with oxidized citronellol will add to the tools in the diagnosis of fragrance allergy.<br /> (© 2020 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.)
- Subjects :
- Acyclic Monoterpenes administration & dosage
Adult
Allergens administration & dosage
Dermatitis, Allergic Contact etiology
Female
Humans
Irritants adverse effects
Male
Middle Aged
Oxidation-Reduction
Perfume administration & dosage
Terpenes adverse effects
Acyclic Monoterpenes adverse effects
Allergens adverse effects
Dermatitis, Allergic Contact diagnosis
Patch Tests methods
Perfume adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0536
- Volume :
- 83
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Contact dermatitis
- Publication Type :
- Academic Journal
- Accession number :
- 32638395
- Full Text :
- https://doi.org/10.1111/cod.13654