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Evaluation of seminal fluid leukocyte subpopulations in patients with varicocele.
- Source :
-
International journal of immunopathology and pharmacology [Int J Immunopathol Pharmacol] 2020 Jan-Dec; Vol. 34, pp. 2058738420925719. - Publication Year :
- 2020
-
Abstract
- Varicocele is a common cause of sperm damage. Some studies showed higher concentration of seminal leukocytes in patients with varicocele. The aim of the study was to evaluate seminal leukocyte subpopulations in patients with varicocele. We enrolled 20 patients with varicocele and 20 age-matched healthy men. Sperm analysis was conducted according to the World Health Organization (WHO) 2010 criteria. We evaluated seminal leukocyte subpopulations and bio-functional sperm parameters by flow cytometry. Patients with varicocele had significantly lower sperm concentration and total number than controls. Regarding seminal leukocyte subpopulations, patients with varicocele had a significantly lower percentage of CD8+ and CD16+ leukocytes and a significantly higher percentage of CD4+ leukocytes than controls. As for bio-functional sperm parameters, we found that patients with varicocele had a significantly lower percentage of alive spermatozoa compared to the control group. These results may explain the increased level of cytokines in the seminal plasma of patients with varicocele.
- Subjects :
- Adult
CD3 Complex analysis
CD4-Positive T-Lymphocytes immunology
CD8-Positive T-Lymphocytes immunology
Case-Control Studies
Cell Survival
Flow Cytometry
GPI-Linked Proteins analysis
Humans
Immunophenotyping
Leukocyte Common Antigens analysis
Lipopolysaccharide Receptors analysis
Male
Phenotype
Prospective Studies
Receptors, IgG analysis
Sperm Count
Varicocele pathology
Leukocytes immunology
Semen immunology
Spermatozoa pathology
Varicocele immunology
Subjects
Details
- Language :
- English
- ISSN :
- 2058-7384
- Volume :
- 34
- Database :
- MEDLINE
- Journal :
- International journal of immunopathology and pharmacology
- Publication Type :
- Editorial & Opinion
- Accession number :
- 32635770
- Full Text :
- https://doi.org/10.1177/2058738420925719