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A randomized, double-blind, placebo-controlled crossover clinical trial to evaluate the anti-diabetic effects of Allium hookeri extract in the subjects with prediabetes.
- Source :
-
BMC complementary medicine and therapies [BMC Complement Med Ther] 2020 Jul 06; Vol. 20 (1), pp. 211. Date of Electronic Publication: 2020 Jul 06. - Publication Year :
- 2020
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Abstract
- Background: Allium hookeri is widely consumed as a vegetable and herbal medicine in Asia. A. hookeri has been reported anti-inflammatory, anti-obesity, osteoblastic, anti-oxidant, and anti-diabetic effects in animal studies. We investigated the anti-diabetic effects of A. hookeri aqueous extract (AHE) in the Korean subjects.<br />Methods: Prediabetic subjects (100 ≤ fasting plasma glucose (FPG) < 126 mg/dL) who met the inclusion criteria were recruited for this study. The enrolled subjects (n = 30) were randomly divided into either an AHE (n = 15, 486 mg/day) or placebo (n = 15) group. Outcomes were measurements of FPG, glycemic response to an oral glucose tolerance test (OGTT), insulin, C-peptide, hemoglobin A1c (HbA1c), total cholesterol, triglyceride, HDL-cholesterol, and LDL-cholesterol. The t-test was used to assess differences between the groups. A p-value < 0.05 was considered statistically significant.<br />Results: Eight weeks after AHE supplementation, HbA1c level was significantly decreased in the AHE group compared with the placebo group. No clinically significant changes in any safety parameter were observed.<br />Conclusion: The findings suggest that AHE can be effective in reducing HbA1c, indicating it as an adjunctive tool for improving glycemic control.<br />Trial Registration: The study protocol was retrospectively registered at www.clinicaltrials.gov ( NCT03330366 , October 30, 2017).
Details
- Language :
- English
- ISSN :
- 2662-7671
- Volume :
- 20
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC complementary medicine and therapies
- Publication Type :
- Academic Journal
- Accession number :
- 32631388
- Full Text :
- https://doi.org/10.1186/s12906-020-03005-3