Permeation of skin with (C 60 ) fullerene dispersions.

Authors :: Martins M
Azoia NG
Melle-Franco M
Ribeiro A
Cavaco-Paulo A
Source :: Engineering in life sciences [Eng Life Sci] 2017 Feb 15; Vol. 17 (7), pp. 732-738. Date of Electronic Publication: 2017 Feb 15 (Print Publication: 2017).
Publication Year :: 2017
Abstract: Dispersions in transcutol/isopropyl myristate make C <subscript>60</subscript> fullerene molecules suitable for transdermal delivery. We found that C <subscript>60</subscript> can successfully permeate the skin using pig skin in Franz diffusion cells. Molecular dynamics simulations and transmission electron microscopy confirmed these observations. Basic cosmetic formulations with transcutol/isopropyl myristate without harsh organic solvents show a high potential for delivery of C <subscript>60</subscript> for biopharmaceutical and cosmetics applications.<br /> (© 2017 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim.)