Fungal Melanin Rewires Macrophage Metabolism.

Authors :: Papon N
Gangneux JP
Delneste Y
Source :: Trends in biochemical sciences [Trends Biochem Sci] 2020 Sep; Vol. 45 (9), pp. 728-730. Date of Electronic Publication: 2020 Jul 01.
Publication Year :: 2020
Abstract: Aspergillus fumigatus is a deadly fungal pathogen in immunocompromised patients. A report by Gonçalves et al. reveals that melanin, a secondary metabolite present at the surface of infecting fungal spores, induces glycolysis in macrophages to promote inflammatory responses. This opens a window for the development of innovative host-directed antifungal therapies.<br /> (Copyright © 2020 Elsevier Ltd. All rights reserved.)