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Gestational outcomes in women infected by Zika virus during pregnancy in Mato Grosso do Sul, Brazil: A cross-sectional study.
- Source :
-
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2020 Sep; Vol. 98, pp. 359-365. Date of Electronic Publication: 2020 Jun 30. - Publication Year :
- 2020
-
Abstract
- Objectives: This study aimed to describe the demographic and clinical parameters of women infected by Zika virus who had infants with stigmata of Congenital Zika Syndrome (CZS) versus those who had normal-appearing infants at birth, thereby providing further details on the clinical caveats of neonatal ZIKV infection.<br />Methodology: This cross-sectional study was performed in the state of Mato Grosso do Sul, Central-West region of Brazil, and included 117 mother-infant pairs who were interviewed and 120 gestational outcomes. All mothers had laboratory confirmation by qRT-PCR of ZIKV infection during pregnancy.<br />Results: The prevalence of congenital abnormalities related to ZIKV was 2.69 cases per 10,000 live births during this period. Exanthem was the main clinical finding, observed in 92.5% of the mothers in this study. Regarding the timing of ZIKV infection, the first trimester was the most frequent time of infection among mothers of infants with CZS (54.55%) (p=0.0007). The case fatality rate was 5% (n=6). Among the 23 children who were classified as having CZS, 13 (56.52%) of them presented with microcephaly. Only 13 (56.52%) children with CZS were tested by qRT-PCR for ZIKV infection at birth, five (38%) were positive.<br />Conclusions: This study highlights the congenital alterations of ZIKV infection during pregnancy in an epidemic burst, demonstrating that the alterations found in other studies are similar to the present research.<br /> (Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Subjects :
- Adult
Brazil epidemiology
Cross-Sectional Studies
Exanthema diagnosis
Exanthema epidemiology
Exanthema physiopathology
Exanthema virology
Female
Humans
Infant
Infant, Newborn
Microcephaly diagnosis
Microcephaly physiopathology
Microcephaly virology
Pregnancy
Pregnancy Complications, Infectious diagnosis
Pregnancy Complications, Infectious physiopathology
Pregnancy Complications, Infectious virology
Pregnancy Outcome
Retrospective Studies
Young Adult
Zika Virus genetics
Zika Virus isolation & purification
Zika Virus physiology
Microcephaly epidemiology
Pregnancy Complications, Infectious epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1878-3511
- Volume :
- 98
- Database :
- MEDLINE
- Journal :
- International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 32619757
- Full Text :
- https://doi.org/10.1016/j.ijid.2020.06.084