CD8 + CD122 + T cell homeostasis is controlled by different levels of IL-15 trans-presentation.

Authors :: Lee GA
Liao NS
Source :: Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi [J Microbiol Immunol Infect] 2021 Jun; Vol. 54 (3), pp. 514-517. Date of Electronic Publication: 2020 Jun 23.
Publication Year :: 2021
Abstract: The homeostasis of CD8 <superscript>+</superscript> CD122 <superscript>+</superscript> T cell requires IL-15 trans-presentation. We use Il15ra mutant mice and bone marrow chimeras to assess the role of IL-15 trans-presentation level in CD8 <superscript>+</superscript> CD122 <superscript>+</superscript> T cells homeostasis. We demonstrate that CD8 <superscript>+</superscript> CD122 <superscript>+</superscript> T cells require different levels of IL-15 trans-presentation to support their homeostasis.<br />Competing Interests: Declaration of Competing Interest All contributing authors declare no conflicts of interest.<br /> (Copyright © 2020. Published by Elsevier B.V.)

Subjects :: Animals
Bone Marrow Cells immunology
CD8-Positive T-Lymphocytes physiology
Interleukin-2 Receptor beta Subunit immunology
Mice
Mice, Inbred C57BL
Stromal Cells immunology
CD8-Positive T-Lymphocytes immunology
Homeostasis immunology
Interleukin-15 immunology
Interleukin-2 Receptor beta Subunit genetics

Language :: English
ISSN :: 1995-9133
Volume :: 54
Issue :: 3
Database :: MEDLINE
Journal :: Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
Publication Type :: Academic Journal
Accession number :: 32616380
Full Text :: https://doi.org/10.1016/j.jmii.2020.06.005

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