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The impact of granulocyte colony-stimulating factor (G-CSF) on thin endometrium of an animal model with rats.
- Source :
-
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] 2021 May; Vol. 37 (5), pp. 438-445. Date of Electronic Publication: 2020 Jul 02. - Publication Year :
- 2021
-
Abstract
- Materials and Methods: After forming of the thin endometrium by uterine injection of 0.2 ml 96% ethyl alcohol to the rats, five days of subcutaneous injections of 40 μg/kg G-CSF or saline were given. Endometrial thickness, immunohistochemically expression of vascular endothelial growth factor receptor-2 (VEGF-R2), proliferative cell nuclear antigen (PCNA) and fibronectin apoptosis with TUNEL method were compared in specimens among four groups of post-model rats.<br />Results: Endometrial thickness was significantly improved in thin but not in normal endometrium group with GCSF when compared to saline injection. Stromal and glandular epithelial expression of PCNA and pericapillary VEGF-R2 was significantly increased, and apoptosis was significantly decreased with G-CSF. Although fibronectin was also increased with G-CSF in the thin endometrium, the difference was non-significant. In further, G-CSF decreased apoptotic cells and increased expression of PCNA when compared to saline injection in normal endometrium.<br />Conclusions: G-CSF improves endometrial thickness, proliferation, angiogenesis and DNA fragmentation in thin endometrium.
Details
- Language :
- English
- ISSN :
- 1473-0766
- Volume :
- 37
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 32611261
- Full Text :
- https://doi.org/10.1080/09513590.2020.1786508