Synaptic Loss in Multiple Sclerosis Spinal Cord.

Authors :: Petrova N
Nutma E
Carassiti D
Rs Newman J
Amor S
Altmann DR
Baker D
Schmierer K
Source :: Annals of neurology [Ann Neurol] 2020 Sep; Vol. 88 (3), pp. 619-625. Date of Electronic Publication: 2020 Jul 16.
Publication Year :: 2020
Abstract: Disability in multiple sclerosis (MS) is considered primarily a result of axonal loss. However, correlation with spinal cord cross-sectional area-a predictor of disability-is poor, questioning the unique role of axonal loss. We investigated the degree of synaptic loss in postmortem spinal cords (18 chronic MS, 8 healthy controls) using immunohistochemistry for synaptophysin and synapsin. Substantial (58-96%) loss of synapses throughout the spinal cord was detected, along with moderate (47%) loss of anterior horn neurons, notably in demyelinating MS lesions. We conclude that synaptic loss is significant in chronic MS, likely contributing to disability accrual. ANN NEUROL 2020;88:619-625.<br /> (© 2020 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.)