Histopathological Features and Ann Arbor Stage in Periocular Lymphoma.

Authors :: Zschoche M
Zimpfer A
Scheef BO
Jünemann AM
Guthoff RF
Junghanss C
Hildebrandt G
Emmert S
Erbersdobler A
Kundt G
Kakkassery V
Source :: In vivo (Athens, Greece) [In Vivo] 2020 Jul-Aug; Vol. 34 (4), pp. 1965-1974.
Publication Year :: 2020
Abstract: Background: To evaluate biodata, symptoms/signs, lymphoma type, localization, stage level, treatment choice and outcome of ocular adnexal lymphoma (OAL).<br />Patients and Methods: A single-center retrospective analysis of 56 patients with OAL was performed from 1998 to 2018.<br />Results: OAL involved the orbit in 44.6%, the conjunctiva in 32.1%, the lacrimal apparatus in 14.3% and the eyelid in 8.93%. Extranodal marginal zone B-cell lymphoma (EMZL) was found in 60.7%, follicular lymphoma (FL) in 21.4%, diffuse large B-cell lymphoma in 7.14%, mantle cell lymphoma in 5.36% and chronic lymphatic leukaemia in 5.36% patients. No relapse was seen in 76%. EMZL and FL had a significantly better overall survival compared to other lymphoma types (p=0.002). Patients with Ann Arbor stage IE had a significantly better prognosis than those with stages higher than IE (p=0.048).<br />Conclusion: Our data suggest that clinicopathological features such as Ann Arbor stage influence survival.<br /> (Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)