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Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Internalizing Behaviors after Early Mild Traumatic Brain Injury.
- Source :
-
Journal of neurotrauma [J Neurotrauma] 2021 Jan 01; Vol. 38 (1), pp. 102-110. Date of Electronic Publication: 2020 Aug 10. - Publication Year :
- 2021
-
Abstract
- Pediatric traumatic brain injury (TBI) can lead to adverse emotional, social, and behavioral consequences. However, outcome is difficult to predict due to significant individual variability, likely reflecting a complex interaction between injury- and child-related variables. Among these variables are genetically determined individual differences, which can modulate TBI outcome through their influence on neuroplasticity mechanisms. In this study, we examined the effect of Val66Met, a common polymorphism of the brain-derived neurotrophic factor gene known to be involved in neuroplasticity mechanisms, on behavioral symptoms of mild TBI (mTBI) sustained in early childhood. This work is part of a prospective, longitudinal cohort study of early TBI. The current sample consisted of 145 children between ages 18 and 60 months assigned to one of three participant groups: mild TBI, orthopedic injury, or typically developing children. Participants provided a saliva sample to detect the presence of the Val66Met polymorphism, and the Child Behavior Checklist was used to document the presence of behavioral symptoms at 6- and 18-months post-injury. Contrary to our initial hypothesis, at 6 months post-injury, non-carriers of the Val66Met polymorphism in the mTBI group presented significantly more internalizing symptoms (e.g., anxiety/depression and somatic complaints) than Val66Met carriers, who were similar to orthopedically injured and typically developing children. However, at 18 months post-injury, all children with mTBI presented more internalizing symptoms, independent of genotype. The results of the study provide evidence for a protective effect of the Val66Met polymorphism on internalizing behavior symptoms 6 months after early childhood mTBI.
- Subjects :
- Adolescent
Alleles
Anxiety genetics
Brain Concussion genetics
Child
Child, Preschool
Depression genetics
Female
Humans
Infant
Longitudinal Studies
Male
Prospective Studies
Anxiety etiology
Brain Concussion complications
Brain-Derived Neurotrophic Factor genetics
Depression etiology
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 1557-9042
- Volume :
- 38
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of neurotrauma
- Publication Type :
- Academic Journal
- Accession number :
- 32605421
- Full Text :
- https://doi.org/10.1089/neu.2019.6936