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Disproportionate burden of coronavirus disease 2019 among racial minorities and those in congregate settings among a large cohort of people with HIV.
- Source :
-
AIDS (London, England) [AIDS] 2020 Oct 01; Vol. 34 (12), pp. 1781-1787. - Publication Year :
- 2020
-
Abstract
- Background: Many people living with HIV (PLWH) have comorbidities which are risk factors for severe coronavirus disease 2019 (COVID-19) or have exposures that may lead to acquisition of severe acute respiratory distress syndrome coronavirus 2. There are few studies, however, on the demographics, comorbidities, clinical presentation, or outcomes of COVID-19 in people with HIV.<br />Objective: To evaluate risk factors, clinical manifestations, and outcomes in a large cohort of PLWH with COVID-19.<br />Methods: We systematically identified all PLWH who were diagnosed with COVID-19 at a large hospital from 3 March to 26 April 2020 during an outbreak in Massachusetts. We analyzed each of the cases to extract information including demographics, medical comorbidities, clinical presentation, and illness course after COVID-19 diagnosis.<br />Results: We describe a cohort of 36 PLWH with confirmed COVID-19 and another 11 patients with probable COVID-19. Almost 85% of PLWH with confirmed COVID-19 had a comorbidity associated with severe disease, including obesity, cardiovascular disease, or hypertension. Approximately 77% of PLWH with COVID-19 were non-Hispanic Black or Latinx whereas only 40% of the PLWH in our clinic were Black or Latinx. Nearly half of PLWH with COVID-19 had exposure to congregate settings. In addition to people with confirmed COVID-19, we identified another 11 individuals with probable COVID-19, almost all of whom had negative PCR testing.<br />Conclusion: In the largest cohort to date of PLWH and confirmed COVID-19, almost all had a comorbidity associated with severe disease, highlighting the importance of non-HIV risk factors in this population. The racial disparities and frequent link to congregate settings in PLWH and COVID-19 need to be explored urgently.
- Subjects :
- Adult
Black or African American statistics & numerical data
Aged
Betacoronavirus
COVID-19
Cohort Studies
Comorbidity
Coronavirus Infections ethnology
Cost of Illness
Female
HIV Infections ethnology
Hispanic or Latino statistics & numerical data
Humans
Male
Massachusetts epidemiology
Middle Aged
Pandemics
Pneumonia, Viral ethnology
Risk Factors
SARS-CoV-2
Coronavirus Infections epidemiology
HIV Infections epidemiology
Pneumonia, Viral epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1473-5571
- Volume :
- 34
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- AIDS (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 32604138
- Full Text :
- https://doi.org/10.1097/QAD.0000000000002607