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The influence of age-of-onset of antidepressant use on the acute CBF response to a citalopram challenge; a pharmacological MRI study.
- Source :
-
Psychiatry research. Neuroimaging [Psychiatry Res Neuroimaging] 2020 Sep 30; Vol. 303, pp. 111126. Date of Electronic Publication: 2020 Jun 13. - Publication Year :
- 2020
-
Abstract
- Preclinical studies have demonstrated that antidepressant treatment in juvenile rodents affect the ontogeny of the serotonin system. However, whether early antidepressant use has similar effects on the development of the serotonin system in humans remains unknown. Therefore, we investigated whether effects of selective serotonin reuptake inhibitor (SSRI) treatment on the serotonin system are modulated by age. With pharmacological Magnetic Resonance Imaging the cerebral blood flow (CBF) response to an acute citalopram challenge was measured, as a proxy for serotonin function. Fifty-one females with major depressive disorder or anxiety disorder were stratified into three groups: 1) those treated with SSRIs <23 years of age, 2) those treated with SSRIs >23 years of age, and 3) those that were never treated with SSRIs. Additionally, a group of 14 healthy controls was included. CBF decreased after a citalopram challenge in the amygdala, hippocampus and orbitofrontal cortex across the whole sample. However, in contrast to preclinical studies, we did not find any age-dependent effect of SSRI exposure on the CBF response. In view of recent concerns on potential adverse effects of SSRIs administered to children, future studies are needed to replicate our negative findings in larger samples sizes and potentially in a prospective design.<br />Competing Interests: Declaration of Competing Interest None of the authors declare a conflict of interest.<br /> (Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Age Factors
Antidepressive Agents, Second-Generation administration & dosage
Anxiety Disorders drug therapy
Cerebrovascular Circulation physiology
Child
Child, Preschool
Cross-Sectional Studies
Depressive Disorder, Major drug therapy
Female
Humans
Infusions, Intravenous
Prospective Studies
Young Adult
Anxiety Disorders diagnostic imaging
Cerebrovascular Circulation drug effects
Citalopram administration & dosage
Depressive Disorder, Major diagnostic imaging
Magnetic Resonance Imaging methods
Selective Serotonin Reuptake Inhibitors administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7506
- Volume :
- 303
- Database :
- MEDLINE
- Journal :
- Psychiatry research. Neuroimaging
- Publication Type :
- Academic Journal
- Accession number :
- 32592855
- Full Text :
- https://doi.org/10.1016/j.pscychresns.2020.111126