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Anaphylactic reactions to biological drugs.
- Source :
-
Current opinion in allergy and clinical immunology [Curr Opin Allergy Clin Immunol] 2020 Aug; Vol. 20 (4), pp. 346-351. - Publication Year :
- 2020
-
Abstract
- Purpose of Review: This review summarizes the current knowledge of the pathogenic mechanisms of biologics-induced anaphylaxis, and the diagnostic and prophylactic strategies in the management of potentially reactive patients, to improve the safety profile of biologics.<br />Recent Findings: The recent knowledge on the topic highlights the involvement of both effector and regulatory mechanisms in the immune response to biological agents. In addition, the impact of biological's immunogenicity on hypersensitivity reactions has been confirmed in a wider number of studies, defining some details about the kinetics of antidrug antibodies development, specifically immunoglobulin G (IgG) and immunoglobulin E (IgE).<br />Summary: Biological agents may induce anaphylaxis, mainly through the induction of antidrug antibodies. Biologics-related infusion reactions are often clinically consistent with type I hypersensitivity, but IgG antidrug antibodies may also be involved. The immune response toward biologicals is orchestrated by both effector and regulatory T cells. In addition, nonantibody-dependent mechanisms may occur. Among clinicians persists today again a low awareness, not only of the possibility to understand the immunological mechanisms behind anaphylaxis to biologicals but also the opportunity to apply potential strategies for the management of reactive patients aimed to guarantee a safe retreatment.
- Subjects :
- Anaphylaxis chemically induced
Anaphylaxis immunology
Anaphylaxis therapy
Biological Products administration & dosage
Drug Hypersensitivity immunology
Drug Hypersensitivity therapy
Humans
Immunoglobulin E immunology
Immunoglobulin G immunology
Infusions, Intravenous
T-Lymphocytes, Cytotoxic immunology
T-Lymphocytes, Regulatory immunology
Anaphylaxis diagnosis
Biological Products adverse effects
Drug Hypersensitivity diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1473-6322
- Volume :
- 20
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Current opinion in allergy and clinical immunology
- Publication Type :
- Academic Journal
- Accession number :
- 32590502
- Full Text :
- https://doi.org/10.1097/ACI.0000000000000666