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Non-steroidal anti-inflammatory drugs increase urinary neutrophil gelatinase-associated lipocalin in recreational runners.
Non-steroidal anti-inflammatory drugs increase urinary neutrophil gelatinase-associated lipocalin in recreational runners.
- Source :
-
Scandinavian journal of medicine & science in sports [Scand J Med Sci Sports] 2020 Oct; Vol. 30 (10), pp. 1888-1895. Date of Electronic Publication: 2020 Aug 13. - Publication Year :
- 2020
-
Abstract
- Objectives: To study the effects of running with/without the use of pain killers on urinary neutrophil gelatinase-associated lipocalin (uNGAL) and other parameters of kidney function in recreational runners.<br />Methods: Participants of the 10- and 21.1-km Weir Venloop race were enrolled and their urine samples collected before and after the run. Urine dipstick and other conventional tests used to assess kidney function were performed. The presence of ibuprofen, diclofenac, naproxen, and/or paracetamol was assessed by LC-MS/MS. uNGAL was measured with a two-step chemiluminescent immunoassay.<br />Results: NSAIDs/analgesics were detected in urine of 5 (14.4%) 10-km runners and 13 (28.9%) 21.1-km runners. Only half-marathon participants showed significant increases in uNGAL (pre: 11.7 [7.1-34.3] ng/mL; post: 33.4 [17.4-50.4] ng/mL; P = .0038). There was a significant effect of NSAID/analgesic use on uNGAL increase (F <subscript>2, 76</subscript>  = 4.210, P = .004). Post hoc tests revealed that uNGAL increased significantly in runners who tested positive for ibuprofen/naproxen compared to runners who did not use any medications (P = .045) or those who tested positive for paracetamol (P = .033). Running distance had a significant influence on the increase in uNGAL (F <subscript>1, 53</subscript>  = 4.741, P < .05), specific gravity (F <subscript>1, 60</subscript>  = 9.231, P < .01), urinary creatinine (F <subscript>1, 61</subscript>  = 10.574, P < .01), albumin (F <subscript>1, 59</subscript>  = 4.888, P < .05), and development of hematuria (χ <superscript>2</superscript> (4) = 18.44, P = .001).<br />Conclusions: Running distance and use of ibuprofen/naproxen were identified as risk factors for uNGAL increase in recreational runners.<br /> (© 2020 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd.)
- Subjects :
- Acetaminophen pharmacology
Acetaminophen urine
Adult
Analysis of Variance
Anti-Inflammatory Agents, Non-Steroidal urine
Diclofenac pharmacology
Diclofenac urine
Female
Humans
Ibuprofen pharmacology
Ibuprofen urine
Kidney physiology
Luminescent Measurements
Male
Middle Aged
Naproxen pharmacology
Naproxen urine
Single-Blind Method
Anti-Inflammatory Agents, Non-Steroidal pharmacology
Lipocalin-2 urine
Running physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0838
- Volume :
- 30
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Scandinavian journal of medicine & science in sports
- Publication Type :
- Academic Journal
- Accession number :
- 32585737
- Full Text :
- https://doi.org/10.1111/sms.13755