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Fatal underhanded chronic enterovirus infection associated with anti-CD20 monotherapy for central nervous system demyelinating disease.

Authors :
Luciani L
Ninove L
Zandotti C
Chalvignac V
Lagier D
Baume J
Mélade J
Piorkowski G
Coutard B
Lepidi H
Pelletier J
Audoin B
Rico-Lamy A
Nougairède A
Source :
Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2021 Feb; Vol. 27 (2), pp. 320-323. Date of Electronic Publication: 2020 Jun 25.
Publication Year :
2021

Abstract

We report a fatal case of coxsackievirus B4 chronic infection in a 30-year-old woman with a diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disorder controlled by rituximab monotherapy for 3 years. Initially presenting as self-limited meningitis, the infection remained silent for 8 months before the sudden onset of fulminant myocarditis. Analysis of the complete genome showed that the same virus was responsible for both episodes.

Details

Language :
English
ISSN :
1477-0970
Volume :
27
Issue :
2
Database :
MEDLINE
Journal :
Multiple sclerosis (Houndmills, Basingstoke, England)
Publication Type :
Academic Journal
Accession number :
32584194
Full Text :
https://doi.org/10.1177/1352458520923978