Back to Search
Start Over
Effect of the inducers of cellular differentiation and of ionizing radiation on thymus lymphocytes: chromatin degradation and programmed cell death.
- Source :
-
International journal of radiation biology and related studies in physics, chemistry, and medicine [Int J Radiat Biol Relat Stud Phys Chem Med] 1988 Apr; Vol. 53 (4), pp. 617-28. - Publication Year :
- 1988
-
Abstract
- The cytotoxic response of thymocytes to chemical inducers of differentiation does not represent a non-specific toxic action of these drugs. The death of thymocytes treated with the inducers or with gamma-rays is associated with internucleosomal chromatin fragmentation. All treatments are more effective on the most radiosensitive sub-population of these cells. This subpopulation is characterized by the maximal level of spontaneous DNA lesions. Incubation of thymocytes with the inducers of differentiation raises the level of these lesions. It is suggested that the processes of thymocyte death after the inducer treatment or irradiation and of cellular differentiation have features in common, and the capacity of thymocytes to limit or reverse the potentially lethal effects of these treatments is determined by the level of pre-existing spontaneous DNA lesions.
- Subjects :
- Animals
Butyrates pharmacology
Butyric Acid
Cell Survival drug effects
Cell Survival radiation effects
Chromatin drug effects
Cobalt Radioisotopes
Dimethyl Sulfoxide pharmacology
Ethionine pharmacology
Gamma Rays
Hypoxanthine
Hypoxanthines pharmacology
Mice
Radiation Genetics
T-Lymphocytes drug effects
Cell Differentiation drug effects
Chromatin radiation effects
T-Lymphocytes radiation effects
Subjects
Details
- Language :
- English
- ISSN :
- 0020-7616
- Volume :
- 53
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International journal of radiation biology and related studies in physics, chemistry, and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 3258296
- Full Text :
- https://doi.org/10.1080/09553008814550941