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A Clerodane Diterpene from Callicarpa americana Resensitizes Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics.
- Source :
-
ACS infectious diseases [ACS Infect Dis] 2020 Jul 10; Vol. 6 (7), pp. 1667-1673. Date of Electronic Publication: 2020 Jun 29. - Publication Year :
- 2020
-
Abstract
- The rise of antibiotic resistance presents a significant healthcare challenge and precludes the use of many otherwise valuable antibiotics. One potential solution to this problem is the use of antibiotics in combination with resistance-modifying agents, compounds that act synergistically with existing antibiotics to resensitize previously resistant bacteria. In this study, 12( S ),16ξ-dihydroxycleroda-3,13-dien-15,16-olide, a clerodane diterpene isolated from the medicinal plant Callicarpa americana , was found to synergize with oxacillin against methicillin-resistant Staphylococcus aureu s. This synergy was confirmed by checkerboard (fractional inhibitory concentration index (FICI) = 0.125) and time-kill assays, with a subinhibitory dose of 12( S ),16ξ-dihydroxycleroda-3,13-dien-15,16-olide causing the effective concentration of oxacillin to fall below the susceptibility breakpoint for S. aureus , a >32-fold decrease in both cases.
Details
- Language :
- English
- ISSN :
- 2373-8227
- Volume :
- 6
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- ACS infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 32579326
- Full Text :
- https://doi.org/10.1021/acsinfecdis.0c00307