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EBV renders B cells susceptible to HIV-1 in humanized mice.
- Source :
-
Life science alliance [Life Sci Alliance] 2020 Jun 23; Vol. 3 (8). Date of Electronic Publication: 2020 Jun 23 (Print Publication: 2020). - Publication Year :
- 2020
-
Abstract
- HIV and EBV are human pathogens that cause a considerable burden to worldwide health. In combination, these viruses are linked to AIDS-associated lymphomas. We found that EBV, which transforms B cells, renders them susceptible to HIV-1 infection in a CXCR4 and CD4-dependent manner in vitro and that CXCR4-tropic HIV-1 integrates into the genome of these B cells with the same molecular profile as in autologous CD4 <superscript>+</superscript> T cells. In addition, we established a humanized mouse model to investigate the in vivo interactions of EBV and HIV-1 upon coinfection. The respective mice that reconstitute human immune system components upon transplantation with CD34 <superscript>+</superscript> human hematopoietic progenitor cells could recapitulate aspects of EBV and HIV immunobiology observed in dual-infected patients. Upon coinfection of humanized mice, EBV/HIV dual-infected B cells could be detected, but were susceptible to CD8 <superscript>+</superscript> T-cell-mediated immune control.<br /> (© 2020 McHugh et al.)
- Subjects :
- Animals
B-Lymphocytes metabolism
B-Lymphocytes pathology
B-Lymphocytes virology
CD4 Antigens immunology
CD4 Antigens metabolism
Coinfection
Disease Models, Animal
Disease Susceptibility metabolism
Disease Susceptibility virology
Epstein-Barr Virus Infections immunology
HIV Infections genetics
HIV Seropositivity
HIV-1 metabolism
HIV-1 pathogenicity
Hematopoietic Stem Cells pathology
Herpesvirus 4, Human immunology
Herpesvirus 4, Human metabolism
Humans
Male
Mice
Mice, Inbred NOD
Receptors, CXCR4 metabolism
Receptors, CXCR4 physiology
T-Lymphocytes immunology
HIV Infections immunology
HIV Infections virology
Herpesvirus 4, Human pathogenicity
Subjects
Details
- Language :
- English
- ISSN :
- 2575-1077
- Volume :
- 3
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Life science alliance
- Publication Type :
- Academic Journal
- Accession number :
- 32576602
- Full Text :
- https://doi.org/10.26508/lsa.202000640