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Update on the target structures of SARS-CoV-2: A systematic review.
- Source :
-
Indian journal of pharmacology [Indian J Pharmacol] 2020 Mar-Apr; Vol. 52 (2), pp. 142-149. Date of Electronic Publication: 2020 Jun 03. - Publication Year :
- 2020
-
Abstract
- Knowledge of structural details is very much essential from the drug-design perspective. In the systematic review, we systematically reviewed the structural basis of different target proteins of SARS-corona virus (CoV2) from a viral life cycle and from drug design perspective. We searched four literature (PubMed, EMBASE, NATURE, and Willey online library) databases and one structural database (RCSB.org) with appropriate keywords till April 18, and finally, 26 articles were included in the systematic review. The published literature mainly centered upon the structural details of "spike protein," "main protease/M Pro/3CL pro," "RNA-dependent RNA polymerase," and "nonstructural protein 15 Endoribonuclease" of SARS-CoV-2. However, inhibitor bound structures were very less. We need better structures elucidating the interactions between different targets and their inhibitors which will help us in understanding the atomic level importance of different amino acid residues in the functionality of the target structures. To summarize, we need structures with fine resolution, co-crystallized structures with biologically validated inhibitors, and functional characterization of different target proteins. Some other routes of entry of SARS-CoV-2 are also mentioned (e.g., CD147); however, these findings are not structurally validated. This review may pave way for better understanding of SARS-CoV-2 life cycle from structural biology perspective.<br />Competing Interests: There are no conflicts of interest.<br /> (Copyright: © 2020 Indian Journal of Pharmacology.)
- Subjects :
- Antiviral Agents pharmacology
Betacoronavirus isolation & purification
COVID-19
Coronavirus Infections virology
Drug Design
Humans
Pandemics
Pneumonia, Viral virology
SARS-CoV-2
COVID-19 Drug Treatment
Betacoronavirus drug effects
Coronavirus Infections drug therapy
Pneumonia, Viral drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1998-3751
- Volume :
- 52
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Indian journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 32565603
- Full Text :
- https://doi.org/10.4103/ijp.IJP_338_20