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First case of SARS-COV-2 sequencing in cerebrospinal fluid of a patient with suspected demyelinating disease.
- Source :
-
Journal of neurology [J Neurol] 2020 Nov; Vol. 267 (11), pp. 3154-3156. Date of Electronic Publication: 2020 Jun 20. - Publication Year :
- 2020
-
Abstract
- The association between coronaviruses and central nervous system (CNS) demyelinating lesions has been previously shown. However, no case has been described of an association between the novel coronavirus (SARS-COV-2) and CNS demyelinating disease so far. SARS-COV-2 was previously detected in cerebrospinal fluid (CSF) sample of a patient with encephalitis. However, the virus identity was not confirmed by deep sequencing of SARS-COV-2 detected in the CSF. Here, we report a case of a patient with mild respiratory symptoms and neurological manifestations compatible with clinically isolated syndrome. The viral genome of SARS-COV-2 was detected and sequenced in CSF with 99.74-100% similarity between the patient virus and worldwide sequences. This report suggests a possible association of SARS-COV-2 infection with neurological symptoms of demyelinating disease, even in the absence of relevant upper respiratory tract infection signs.
Details
- Language :
- English
- ISSN :
- 1432-1459
- Volume :
- 267
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of neurology
- Publication Type :
- Academic Journal
- Accession number :
- 32564153
- Full Text :
- https://doi.org/10.1007/s00415-020-09996-w