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Detection of Respiratory Syncytial Virus or Rhinovirus Weeks After Hospitalization for Bronchiolitis and the Risk of Recurrent Wheezing.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2021 Feb 03; Vol. 223 (2), pp. 268-277. - Publication Year :
- 2021
-
Abstract
- Background: In severe bronchiolitis, it is unclear if delayed clearance or sequential infection of respiratory syncytial virus (RSV) or rhinovirus (RV) is associated with recurrent wheezing.<br />Methods: In a 17-center severe bronchiolitis cohort, we tested nasopharyngeal aspirates (NPA) upon hospitalization and 3 weeks later (clearance swab) for respiratory viruses using PCR. The same RSV subtype or RV genotype in NPA and clearance swab defined delayed clearance (DC); a new RSV subtype or RV genotype at clearance defined sequential infection (SI). Recurrent wheezing by age 3 years was defined per national asthma guidelines.<br />Results: Among 673 infants, RSV DC and RV DC were not associated with recurrent wheezing, and RSV SI was rare. The 128 infants with RV SI (19%) had nonsignificantly higher risk of recurrent wheezing (hazard ratio [HR], 1.31; 95% confidence interval [CI], .95-1.80; P = .10) versus infants without RV SI. Among infants with RV at hospitalization, those with RV SI had a higher risk of recurrent wheezing compared to children without RV SI (HR, 2.49; 95% CI, 1.22-5.06; P = .01).<br />Conclusions: Among infants with severe bronchiolitis, those with RV at hospitalization followed by a new RV infection had the highest risk of recurrent wheezing.<br /> (© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
- Subjects :
- Bronchiolitis diagnosis
Bronchiolitis virology
Coinfection virology
Cross Infection virology
Humans
Incidence
Molecular Typing
Picornaviridae Infections virology
Proportional Hazards Models
Recurrence
Respiratory Syncytial Virus Infections virology
Respiratory Syncytial Virus, Human classification
Respiratory Syncytial Virus, Human genetics
Rhinovirus classification
Rhinovirus genetics
Viral Load
Bronchiolitis epidemiology
Coinfection epidemiology
Cross Infection epidemiology
Hospitalization
Picornaviridae Infections epidemiology
Respiratory Sounds
Respiratory Syncytial Virus Infections epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 223
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 32564083
- Full Text :
- https://doi.org/10.1093/infdis/jiaa348