Back to Search
Start Over
Endoplasmic reticulum as a potential therapeutic target for covid-19 infection management?
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 2020 Sep 05; Vol. 882, pp. 173288. Date of Electronic Publication: 2020 Jun 17. - Publication Year :
- 2020
-
Abstract
- In December 2019, many pneumonia cases with unidentified sources appeared in Wuhan, Hubei, China, with clinical symptoms like viral pneumonia. Deep sequencing analysis of samples from lower respiratory tract revealed a novel coronavirus, called 2019 novel coronavirus (2019-nCoV). Currently there is a rapid global spread. World Health Organization declare the disease a pandemic condition. The pathologic source of this disease was a new RNA virus from Coronaviridae family, which was named COVID-19. SARS-CoV-2 entry starts with the binding of the spike glycoprotein expressed on the viral envelope to ACE2 on the alveolar surface followed by clathrin-dependent endocytosis of the SARS-CoV-2 and ACE2 complex. SARS-CoV-2 enters the cells through endocytosis process, which is possibly facilitated, via a pH dependent endosomal cysteine protease cathepsins. Once inside the cells, SARS-CoV-2 exploits the endogenous transcriptional machinery of alveolar cells to replicate and spread through the entire lung. Endosomal acidic pH for SARS-CoV-2 processing and internalization is critical. After entering the cells, it possibly activates or hijack many intracellular pathways in favor of its replication. In the current opinion article, we will explain the possible involvement of unfolded protein response as a cellular stress response to the SARS-CoV-2 infection.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Subjects :
- Alveolar Epithelial Cells cytology
Alveolar Epithelial Cells metabolism
Alveolar Epithelial Cells virology
Angiotensin-Converting Enzyme 2
Betacoronavirus metabolism
COVID-19
Clathrin-Coated Vesicles drug effects
Clathrin-Coated Vesicles metabolism
Coronavirus Infections virology
Endocytosis drug effects
Endoplasmic Reticulum metabolism
Endosomes drug effects
Endosomes metabolism
Humans
Ionophores therapeutic use
Pandemics
Peptidyl-Dipeptidase A metabolism
Pneumonia, Viral virology
SARS-CoV-2
Unfolded Protein Response drug effects
COVID-19 Drug Treatment
Alveolar Epithelial Cells drug effects
Coronavirus Infections drug therapy
Endoplasmic Reticulum drug effects
Ionophores pharmacology
Pneumonia, Viral drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0712
- Volume :
- 882
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 32561291
- Full Text :
- https://doi.org/10.1016/j.ejphar.2020.173288