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Adverse perinatal outcome and placental abnormalities in pregnancies with major fetal congenital heart defects: A retrospective case-control study.
- Source :
-
Prenatal diagnosis [Prenat Diagn] 2020 Oct; Vol. 40 (11), pp. 1390-1397. Date of Electronic Publication: 2020 Aug 12. - Publication Year :
- 2020
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Abstract
- Objective: The placental development has been shown to be compromised in pregnancies affected by fetal congenital heart defects (CHD). This study aimed to investigate the frequency of complications related to utero-placental insufficiency in pregnancies with and without major CHD.<br />Method: This retrospective case-control study was conducted at a Fetal Echocardiography Center in Milan. The following outcomes were compared between the two groups: preeclampsia (PE), small for gestational age (SGA), placental disorders and preterm birth (PTB). The logistic regression analysis was adjusted for maternal age, parity, co-morbidities and mode of conception.<br />Results: The CHD group (n = 480) showed significantly increased incidence of PE (2.9% vs 0.9%; aOR, 6.50; 95% CI, 1.39-30.41; P = .017) as compared to the control group (n = 456). Placental disorders occurred more frequently in the CHD than in controls, but the increased risk showed only a borderline significance (4.5% vs 3.3%; aOR, 2.56; 95% CI, 0.99-1.02; P = .046). There was a significantly higher risk of SGA in CHD than in controls (8.7% vs 3.9%; aOR, 3.37; 95% CI, 1.51-7.51; P = .003). PTB occurred in 65/477 (13.6%) cases and in 39/447 (8.7%) controls (P = .022) (aOR, 2.17; 95% CI, 1.24-3.81; P = .007).<br />Conclusion: Major CHD are significantly associated with the risk of PE, SGA and PTB.<br /> (© 2020 John Wiley & Sons, Ltd.)
Details
- Language :
- English
- ISSN :
- 1097-0223
- Volume :
- 40
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Prenatal diagnosis
- Publication Type :
- Academic Journal
- Accession number :
- 32557693
- Full Text :
- https://doi.org/10.1002/pd.5770