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Admission Low-Density Lipoprotein Cholesterol Stratified by Circulating CD14++CD16+ Monocytes and Risk for Recurrent Cardiovascular Events Following ST Elevation Myocardial Infarction: Lipid Paradox Revised.
- Source :
-
Journal of cardiovascular translational research [J Cardiovasc Transl Res] 2020 Dec; Vol. 13 (6), pp. 916-927. Date of Electronic Publication: 2020 Jun 18. - Publication Year :
- 2020
-
Abstract
- Lower level of low-density lipoprotein cholesterol (LDL-C) is paradoxically associated with increased mortality in ST elevation myocardial infarction (STEMI) patients. The underlying mechanism remains unclear. In a cohort of 220 de novo STEMI patients receiving timely primary percutaneous coronary intervention, admission LDL-C was negatively associated with circulating CD14++CD16+ monocyte counts. Moreover, admission LDL-C <ā85 mg/dL was associated with increased risk for major adverse cardiovascular events (MACE) during a median follow-up of 2.7 years. After categorizing the patients according to the cutoff values of 85 mg/dL for LDL-C and the median for CD14++CD16+ monocytes, low LDL-C-associated MACE risk was only observed in those with high CD14++CD16+ monocyte counts (low LDL-C/high CD14++CD16+ monocytes vs. low LDL-C/low CD14++CD16+ monocytes: hazard ratio 5.38, 95% confidence interval 1.52 to 19.06, Pā=ā0.009). This work provided the proof-of-principle evidence indicating a role of CD14++CD16+ monocytes in risk stratification of STEMI patients presenting with low LDL-C level. Graphical abstract.
- Subjects :
- Aged
Biomarkers blood
Female
GPI-Linked Proteins blood
Humans
Immunity, Innate
Male
Middle Aged
Monocytes immunology
Percutaneous Coronary Intervention adverse effects
Proof of Concept Study
Recurrence
Risk Assessment
Risk Factors
ST Elevation Myocardial Infarction diagnosis
ST Elevation Myocardial Infarction immunology
ST Elevation Myocardial Infarction therapy
Time Factors
Treatment Outcome
Cholesterol, LDL blood
Lipopolysaccharide Receptors blood
Monocytes metabolism
Patient Admission
Receptors, IgG blood
ST Elevation Myocardial Infarction blood
Subjects
Details
- Language :
- English
- ISSN :
- 1937-5395
- Volume :
- 13
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of cardiovascular translational research
- Publication Type :
- Academic Journal
- Accession number :
- 32557321
- Full Text :
- https://doi.org/10.1007/s12265-020-10015-6