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Chemical purification of 111 Ag from isobaric impurity 111 Cd by solid phase extraction chromatography: a proof of concept study.
- Source :
-
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2020 Oct; Vol. 164, pp. 109263. Date of Electronic Publication: 2020 Jun 09. - Publication Year :
- 2020
-
Abstract
- Silver-111 ( <superscript>111</superscript> Ag, t <subscript>1/2</subscript>  = 7.47 d) is a β <superscript>-</superscript> emitter suitable for targeted cancer therapy due to favourable decay properties. The production of no-carrier added <superscript>111</superscript> Ag via Isotope Separation On-Line (ISOL) technique is being investigated at the Legnaro National Laboratories of the Italian Institute of Nuclear Physics (ISOLPHARM project). Stable Cadmium-111 ( <superscript>111</superscript> Cd) is co-produced as isobaric contaminant, hence a chemical separation process must be developed to selectively harvest <superscript>111</superscript> Ag. In this study, a chromatographic procedure employing the commercially available CL resin was investigated by using stable Ag <superscript>+</superscript> and Cd <superscript>2+</superscript> . Results indicate that CL resin allows to efficiently separate Ag <superscript>+</superscript> from Cd <superscript>2+</superscript> and recover the former with high yields.<br /> (Copyright © 2020 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1872-9800
- Volume :
- 164
- Database :
- MEDLINE
- Journal :
- Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 32554124
- Full Text :
- https://doi.org/10.1016/j.apradiso.2020.109263