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Pregnancy-induced Cardiovascular Pathologies: Importance of Structural Components and Lipids.

Authors :
Aleksenko L
Quaye IK
Source :
The American journal of the medical sciences [Am J Med Sci] 2020 Nov; Vol. 360 (5), pp. 447-466. Date of Electronic Publication: 2020 May 13.
Publication Year :
2020

Abstract

Pregnancy leads to adaptations for maternal and fetal energy needs. The cardiovascular system bears the brunt of the adaptations as the heart and vessels enable nutrient supply to maternal organs facilitated by the placenta to the fetus. The components of the cardiovascular system are critical in the balance between maternal homeostatic and fetus driven homeorhetic regulation. Since lipids intersect maternal cardiovascular function and fetal needs with growth and in stress, factors affecting lipid deposition and mobilization impact risk outcomes. Here, the cardiovascular components and functional derangements associated with cardiovascular pathology in pregnancy, vis-à-vis lipid deposition, mobilization and maternal and/or cardiac and fetal energy needs are detailed. Most reports on the components and associated pathology in pregnancy, are on derangements affecting the extracellular matrix and epicardial fat, followed by the endothelium, vascular smooth muscle, pericytes and myocytes. Targeted studies on all cardiovascular components and pathological outcomes in pregnancy will enhance targeted interventions.<br /> (Copyright © 2020 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1538-2990
Volume :
360
Issue :
5
Database :
MEDLINE
Journal :
The American journal of the medical sciences
Publication Type :
Academic Journal
Accession number :
32540145
Full Text :
https://doi.org/10.1016/j.amjms.2020.05.014