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Olfactory and Oral Manifestations of COVID-19: Sex-Related Symptoms-A Potential Pathway to Early Diagnosis.
- Source :
-
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery [Otolaryngol Head Neck Surg] 2020 Oct; Vol. 163 (4), pp. 722-728. Date of Electronic Publication: 2020 Jun 16. - Publication Year :
- 2020
-
Abstract
- Objective: The coronavirus disease 2019 (COVID-19) pandemic poses a threat to global health. Early diagnosis is an essential key to limit the outbreak of the virus.<br />Study Design: Case series, study conducted between March 25, 2020, and April 15, 2020.<br />Setting: Ambulatory, nonhospitalized patients who were quarantined in a designated hotel for COVID-19 patients and were recruited by an advertisement at the hotel.<br />Subjects and Methods: In total, 140 patients participated in a web-based questionnaire assessing initial symptoms of common viral diseases, olfactory and taste functions, xerostomia, and orofacial pain.<br />Results: A total of 58 men and 70 women participated. Initial symptoms were cough (59.4%), weakness (47.7%), myalgia (46.9%), fever (42.2%), headache (40.6%), impaired sense of smell (38.3%), impaired sense of taste (32.8%), sore throat (26.6%), runny nose (26.6%), and nasal congestion (22.7%). All symptoms were more frequent among women; however, only runny nose was statistically significant ( P = .018). The most common combination of symptoms was cough and weakness (37.5%). A total of 25.8% reported olfactory and taste dysfunctions in the absence of other symptoms. In a comparison between the sexes, cough and runny nose were the most common combination in women ( P = .018). A total of 38.3% of patients reported olfactory dysfunction as an initial symptom. Anosmia and facial pain were more common among women ( P < .001 and P = .01, respectively), and 56% of patients reported xerostomia.<br />Conclusion: A considerable number of patients presented with olfactory and oral disorders. Interestingly, women presented with a different cluster of symptoms than men, which may suggest a new clinical approach to diagnosing COVID-19 disease.
- Subjects :
- Adolescent
Adult
Aged
COVID-19
Coronavirus Infections diagnosis
Coronavirus Infections epidemiology
Female
Humans
Male
Middle Aged
Nasal Obstruction diagnosis
Olfaction Disorders diagnosis
Pandemics
Pneumonia, Viral diagnosis
Pneumonia, Viral epidemiology
Retrospective Studies
SARS-CoV-2
Young Adult
Betacoronavirus
Coronavirus Infections complications
Early Diagnosis
Nasal Obstruction etiology
Olfaction Disorders etiology
Pneumonia, Viral complications
Smell physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6817
- Volume :
- 163
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 32539587
- Full Text :
- https://doi.org/10.1177/0194599820934380