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Pharmacokinetic Parameters of Watermelon (Rind, Flesh, and Seeds) Bioactive Components in Human Plasma: A Pilot Study to Investigate the Relationship to Endothelial Function.
- Source :
-
Journal of agricultural and food chemistry [J Agric Food Chem] 2020 Jul 15; Vol. 68 (28), pp. 7393-7403. Date of Electronic Publication: 2020 Jun 30. - Publication Year :
- 2020
-
Abstract
- This study aimed to investigate the metabolic fate of bioactive components in watermelon and explore their effect on endothelial function. Six healthy overweight/obese (BMI: 28.7 ± 1.6 kg/m <superscript>2</superscript> ) adults received 100 kcal of watermelon flesh (WF), rind (WR), seeds (WS), or control meal. l-Citrulline, arginine, and (poly)phenolic metabolites were characterized in plasma over 24 h using UHPLC-MS. Endothelial function was assessed using a flow mediated dilation (FMD) technique over 7 h. Maximum concentration ( C <subscript>max</subscript> ) and area under the curve (AUC <subscript>0-8h</subscript> ) of l-citrulline were significantly higher after WF- and WR-containing test meals compared to control ( p < 0.05). Likewise, several individual phenolic metabolites in plasma had significantly higher C <subscript>max</subscript> after WR, WF, or WS intake compared to control. FMD responses were not different among test meals. Our results provide insights on circulating metabolites from watermelon flesh, seed, and rind and lay the foundation for future clinical trials on vascular benefits of watermelon.
- Subjects :
- Adult
Citrullus chemistry
Female
Fruit chemistry
Fruit metabolism
Humans
Male
Pilot Projects
Seeds chemistry
Seeds metabolism
Vasodilator Agents chemistry
Young Adult
Arginine blood
Citrulline blood
Citrullus metabolism
Endothelial Cells physiology
Obesity blood
Overweight blood
Phenols blood
Vasodilator Agents blood
Subjects
Details
- Language :
- English
- ISSN :
- 1520-5118
- Volume :
- 68
- Issue :
- 28
- Database :
- MEDLINE
- Journal :
- Journal of agricultural and food chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 32538082
- Full Text :
- https://doi.org/10.1021/acs.jafc.0c02756