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Syndromic and Systemic Diagnoses Associated With Isolated Sagittal Synostosis.

Authors :: Davis AA
Haredy MM
Huey J
Scanga H
Zuccoli G
Pollack IF
Tamber MS
Goldstein J
Madan-Khetarpal S
Nischal KK
Source :: Plastic and reconstructive surgery. Global open [Plast Reconstr Surg Glob Open] 2019 Dec 30; Vol. 7 (12), pp. e2540. Date of Electronic Publication: 2019 Dec 30 (Print Publication: 2019).
Publication Year :: 2019
Abstract: Reports of systemic associations in patients with Isolated Sagittal Synostosis (ISS) are sparse. Craniofacial surgeons, and other providers, should be aware that a significant proportion of patients with ISS may have syndromic or systemic involvement. This study investigates the incidence of systemic disease and syndromic diagnosis in a cohort of patients presenting with ISS (ie, patients with sagittal synostosis without other sutural involvement). Methods: This study consists of a retrospective review of patients diagnosed with ISS between 2007 and 2017 at a single institution. Patients were divided according to onset (early <1 year, late >1 year) of ISS. Patient notes were examined for congenital anomalies, systemic conditions, and molecular testing. Only patients with isolated sagittal fusion-meaning, patients with sagittal synostosis and no other sutural involvement-were included. Results: Three hundred seventy-seven patients met the inclusion criteria: systemic conditions were identified in 188/377 (50%) of them. One hundred sixty-one patients with early onset (Group A), and 216 patients with late onset ISS (Group B) were identified. Systemic involvement was identified in 38% of Group A and 60% of Group B, which was statistically significant ( P < 0.001). Forty-eight of 377 (13%) of patients had a syndromic diagnosis, and 79% of these were confirmed via genetic testing. Thirty-five percent of patients were diagnosed with central nervous system anomalies and 16% had craniofacial anomalies. Conclusions: Nearly 50% of the patients initially diagnosed with ISS were found to have some form of systemic involvement. This supports affording full pediatric and genetic evaluation with molecular testing to these children. Competing Interests: Disclosure: The authors have no financial interest to declare in relation to the content of this article. (Copyright © 2019 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons.)