Association between Fetal MTHFR A1298C (rs1801131) Polymorphism and Neural Tube Defects Risk: A Systematic Review and Meta-Analysis.

Authors :: Soleimani-Jadidi S
Meibodi B
Javaheri A
Tabatabaei RS
Hadadan A
Zanbagh L
Abbasi H
Bahrami R
Mirjalili SR
Karimi-Zarchi M
Neamatzadeh H
Source :: Fetal and pediatric pathology [Fetal Pediatr Pathol] 2022 Feb; Vol. 41 (1), pp. 116-133. Date of Electronic Publication: 2020 Jun 14.
Publication Year :: 2022
Abstract: Background: The association of the fetal MTHFR A1298C (rs1801131) polymorphism and neural tube defects (NTDs) susceptibility has been widely demonstrated, but the results remain inconclusive. Thus, we performed a meta-analysis to investigate the association between fetal MTHFR A1298C polymorphism and NTDs risk.<br />Methods: An electronic search of PubMed, web of science, SciELO, CNKI database for studies on the fetal MTHFR A1298C polymorphism and NTDs risk was performed up to March 30, 2020.<br />Results: A total of 22 case-control studies with 3,224 fetuses with NTDs and 3,295 controls were selected. Overall, pooled data showed that the fetal MTHFR A1298C polymorphism was not significantly associated with risk an increased risk of NTDs in the global population. When stratified analysis by ethnicity, country of origin and NTDs type, still no statistically significant association was found.<br />Conclusions: Our pooled data emerged no evidence for significant association between fetal MTHFR A1298C polymorphism and NTDs risk.

Subjects :: Case-Control Studies
Female
Fetus
Genetic Predisposition to Disease
Genotype
Humans
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Pregnancy
Prenatal Care
Methylenetetrahydrofolate Reductase (NADPH2) genetics
Neural Tube Defects genetics

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