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The intriguing commonality of NETosis between COVID-19 & Periodontal disease.
- Source :
-
Medical hypotheses [Med Hypotheses] 2020 Nov; Vol. 144, pp. 109968. Date of Electronic Publication: 2020 Jun 07. - Publication Year :
- 2020
-
Abstract
- NETosis, being an alternative form of cell death is the creation of web-like chromatin decondensates by suitably primed neutrophils as a response to stimulus aimed at containing and eliminating the same. In certain situations, it causes more harm than benefit in the form of bystander damage directly or via activation of autoimmune mechanisms. Such pathophysiology finds evidence in both Periodontal disease and COVID-19. Coupled with impaired removal, NETs have been implicated in both these disease forms to promote a state of inflammation and be a source of constant harm to the tissues involved. This potentially forms groundwork to implicate Periodontal disease as predisposing towards adverse COVID-19 related outcomes.<br /> (Copyright © 2020 Elsevier Ltd. All rights reserved.)
- Subjects :
- Bronchoalveolar Lavage Fluid cytology
Bronchoalveolar Lavage Fluid immunology
COVID-19 complications
COVID-19 physiopathology
Humans
Models, Immunological
Neutrophils physiology
Pandemics
Periodontal Diseases physiopathology
Respiratory Distress Syndrome etiology
Respiratory Distress Syndrome immunology
COVID-19 immunology
Extracellular Traps immunology
Periodontal Diseases immunology
SARS-CoV-2 physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2777
- Volume :
- 144
- Database :
- MEDLINE
- Journal :
- Medical hypotheses
- Publication Type :
- Editorial & Opinion
- Accession number :
- 32534340
- Full Text :
- https://doi.org/10.1016/j.mehy.2020.109968