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Role of γδT cells in liver diseases and its relationship with intestinal microbiota.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2020 May 28; Vol. 26 (20), pp. 2559-2569. - Publication Year :
- 2020
-
Abstract
- γδT cells are unconventional T lymphocytes that bridge innate and adaptive immunity. Based on the composition of T cell receptor and the cytokines produced, γδT cells can be divided into diverse subsets that may be present at different locations, including the liver, epithelial layer of the gut, the dermis and so on. Many of these cells perform specific functions in liver diseases, such as viral hepatitis, autoimmune liver diseases, non-alcoholic fatty liver disease, liver cirrhosis and liver cancers. In this review, we discuss the distribution, subsets, functions of γδT cells and the relationship between the microbiota and γδT cells in common hepatic diseases. As γδT cells have been used to cure hematological and solid tumors, we are interested in γδT cell-based immunotherapies to treat liver diseases.<br />Competing Interests: Conflict-of-interest statement: There is no conflict of interest associated with the contributions of the senior author or other coauthors to this manuscript.<br /> (©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.)
- Subjects :
- Animals
Disease Models, Animal
Humans
Intestinal Mucosa immunology
Intestinal Mucosa microbiology
Intraepithelial Lymphocytes transplantation
Liver immunology
Liver pathology
Liver Diseases microbiology
Liver Diseases pathology
Liver Diseases therapy
Gastrointestinal Microbiome immunology
Immunotherapy methods
Intraepithelial Lymphocytes immunology
Liver Diseases immunology
Subjects
Details
- Language :
- English
- ISSN :
- 2219-2840
- Volume :
- 26
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 32523311
- Full Text :
- https://doi.org/10.3748/wjg.v26.i20.2559