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Microcystic Meningiomas: MRI-Pathologic Correlation.
- Source :
-
Journal of neuroimaging : official journal of the American Society of Neuroimaging [J Neuroimaging] 2020 Sep; Vol. 30 (5), pp. 704-718. Date of Electronic Publication: 2020 Jun 10. - Publication Year :
- 2020
-
Abstract
- Background and Purpose: Microcystic meningiomas (MM) are a distinctive, rare subtype of Grade I meningiomas with limited radiological descriptions. We intend to identify unique imaging phenotypes and seek radiopathological correlations.<br />Methods: Retrospective analysis of histopathologically proven MM was undertaken. Clinicodemographic profiles, imaging, and histopathological characteristics were recorded. Spearman rank correlations among radiological and pathological attributes were performed.<br />Results: Twenty-eight cases were analyzed (mean age = 45.5 years; M:F = 1:1.54; mean volume = 50.1 mL; supratentorial n = 27). Most lesions were markedly T2 hyperintense (higher than peritumoral brain edema-a unique finding) (89.3%) and showed invariable diffusion restriction, severe peritumoral brain edema (edema index >2 in 64.3%), a "storiform" pattern on T2-weighted images (T2WI) (75%), reticular pattern on postcontrast T1 (78.6%)/diffusion-weighted images (DWI) (65.4%), hyperperfusion, T1 hypointensity (84.6%), and absence of blooming on susceptibility-weighted image (80.9%). Storiform/reticular morphology correlated with large cysts on histopathology (ρ = .56; P = .005753).  Lesion dimension positively correlated with reticular morphology on imaging (ρ = .59; P = .001173), higher flow voids (ρ = .65; P = .00027), and greater microcystic changes on histopathology (ρ = .51; P = .006778). Peritumoral brain edema was higher for lesions demonstrating greater angiomatous component (ρ = .46; P = .014451).<br />Conclusions: We have elucidated varied neuroimaging features and highlighted pathological substrates of crucial imaging findings of MM. MM ought to be considered as an imaging possibility in an extra-axial lesion with a marked hypodensity on noncontrast computed tomography, markedly T2-hyperintense/T1-hypointense signal, and a storiform/reticular pattern on T2W/GdT1w//DWI.<br /> (© 2020 American Society of Neuroimaging.)
- Subjects :
- Adult
Aged
Brain pathology
Diffusion Magnetic Resonance Imaging
Female
Humans
Magnetic Resonance Imaging methods
Male
Meningeal Neoplasms pathology
Meningioma pathology
Middle Aged
Radiography
Retrospective Studies
Tomography, X-Ray Computed
Brain diagnostic imaging
Meningeal Neoplasms diagnostic imaging
Meningioma diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1552-6569
- Volume :
- 30
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of neuroimaging : official journal of the American Society of Neuroimaging
- Publication Type :
- Academic Journal
- Accession number :
- 32521093
- Full Text :
- https://doi.org/10.1111/jon.12743