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Resistance Training during Chemotherapy with Doxorubicin.
- Source :
-
Medicine and science in sports and exercise [Med Sci Sports Exerc] 2020 Dec; Vol. 52 (12), pp. 2529-2537. - Publication Year :
- 2020
-
Abstract
- Previous research has shown that resistance training (RT) before doxorubicin (DOX) treatment attenuates the decline in muscle dysfunction; however, the effect of RT during DOX treatment is less known.<br />Purpose: Investigate the effects of RT before and during a 4-wk course of incremental DOX treatment on skeletal muscle function.<br />Methods: Male, Sprague-Dawley rats (N = 36) were randomly assigned to the following groups: sedentary+saline (SED + SAL), sedentary+DOX (SED + DOX), RT + SAL, or RT + DOX. The RT protocol utilized a raised cage model, which provided progressive hindlimb loading throughout the 14-wk study, whereas SED animals were kept in normal housing. Starting at week 10, DOX-treated animals received 3 mg·kg DOX weekly for 4 wk (12 mg·kg cumulative); whereas SAL-treated groups received 0.9% NaCl as a placebo. Grip strength was recorded at 0, 10, 12, and 14 wk. Ex vivo muscle function was performed on excised soleus (SOL) and extensor digitorum longus (EDL) from the right hind limb 5 d after the last injection and were analyzed for expression of creatine kinase (CK) and creatine transporters.<br />Results: SED + DOX-treated animals had significantly lower EDL mass compared with SED + SAL- and RT + DOX-treated animals. Grip strength, EDL maximal force, and EDL force development were significantly lower in SED + DOX-treated animals compared with RT + SAL and SED + SAL. No significant differences in EDL function were found between RT + DOX and RT + SAL animals. DOX treatment reduced expression of CK in the SOL, which abated with RT.<br />Conclusions: Low-intensity RT may attenuate the decline in skeletal muscle function during incremental DOX treatment.
- Subjects :
- Animals
Antibiotics, Antineoplastic adverse effects
Creatine Kinase metabolism
Doxorubicin adverse effects
Drug Administration Schedule
Hindlimb
Male
Membrane Transport Proteins metabolism
Muscle, Skeletal metabolism
Muscle, Skeletal physiology
Random Allocation
Rats, Sprague-Dawley
Saline Solution administration & dosage
Sedentary Behavior
Time Factors
Antibiotics, Antineoplastic administration & dosage
Doxorubicin administration & dosage
Hand Strength physiology
Muscle Strength drug effects
Muscle Strength physiology
Resistance Training methods
Subjects
Details
- Language :
- English
- ISSN :
- 1530-0315
- Volume :
- 52
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Medicine and science in sports and exercise
- Publication Type :
- Academic Journal
- Accession number :
- 32520871
- Full Text :
- https://doi.org/10.1249/MSS.0000000000002409