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Hepatoprotective Effects of Streptococcus thermophilus LM1012 in Mice Exposed to Air Pollutants.
- Source :
-
Journal of medicinal food [J Med Food] 2020 Aug; Vol. 23 (8), pp. 852-861. Date of Electronic Publication: 2020 Jun 08. - Publication Year :
- 2020
-
Abstract
- In this study, we explored whether the use of Streptococcus thermophilus LM1012 (TL-LM1012) as a safe probiotic exerts hepatoprotective effects by suppressing oxidative stress and inflammation in vitro and alleviating aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) production in vivo . In a series of safety tests, TL-LM1012 was found to have a negative response to hemolysis and biogenic amines, as well as susceptibility to antibiotics. TL-LM1012 protected cell viability and suppressed cytotoxicity by inhibiting oxidative stress and induced heme oxygenase-1 and superoxide dismutase activity in a dose-dependent manner in diesel exhaust particulate matter (DEPM)-treated HepG2 cells. Moreover, proinflammatory cytokines, including tumor necrosis factor- α , interleukin (IL)-6, and IL-1 β , were suppressed in DEPM-treated splenocytes. In DEPM-treated mice, oral administration of TL-LM1012 regulated AST, ALT, and LDH production in the serum after 14 days of treatment. These findings indicate that TL-LM1012, a safe probiotic, provides a potent preventive or therapeutic effect against liver disease caused by air pollution.
- Subjects :
- Alanine Transaminase metabolism
Animals
Aspartate Aminotransferases metabolism
Chemical and Drug Induced Liver Injury metabolism
Cytokines
Hep G2 Cells
Humans
Liver metabolism
Liver microbiology
Mice
Oxidative Stress
Particulate Matter toxicity
Vehicle Emissions toxicity
Air Pollutants toxicity
Chemical and Drug Induced Liver Injury prevention & control
Probiotics therapeutic use
Streptococcus thermophilus
Subjects
Details
- Language :
- English
- ISSN :
- 1557-7600
- Volume :
- 23
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of medicinal food
- Publication Type :
- Academic Journal
- Accession number :
- 32513044
- Full Text :
- https://doi.org/10.1089/jmf.2019.4636