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Single-Session Bronchial Thermoplasty Guided by 129 Xe Magnetic Resonance Imaging. A Pilot Randomized Controlled Clinical Trial.
- Source :
-
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2020 Aug 15; Vol. 202 (4), pp. 524-534. - Publication Year :
- 2020
-
Abstract
- Rationale: Adverse events have limited the use of bronchial thermoplasty (BT) in severe asthma. Objectives: We sought to evaluate the effectiveness and safety of using <superscript>129</superscript> Xe magnetic resonance imaging ( <superscript>129</superscript> Xe MRI) to prioritize the most involved airways for guided BT. Methods: Thirty subjects with severe asthma were imaged with volumetric computed tomography and <superscript>129</superscript> Xe MRI to quantitate segmental ventilation defects. Subjects were randomized to treatment of the six most involved airways in the first session (guided group) or a standard three-session BT (unguided). The primary outcome was the change in Asthma Quality of Life Questionnaire score from baseline to 12 weeks after the first BT for the guided group compared with after three treatments for the unguided group. Measurements and Main Results: There was no significant difference in quality of life after one guided compared with three unguided BTs (change in Asthma Quality of Life Questionnaire guided = 0.91 [95% confidence interval, 0.28-1.53]; unguided = 1.49 [95% confidence interval, 0.84-2.14]; P = 0.201). After one BT, the guided group had a greater reduction in the percentage of poorly and nonventilated lung from baseline when compared with unguided (-17.2%; P = 0.009). Thirty-three percent experienced asthma exacerbations after one guided BT compared with 73% after three unguided BTs ( P = 0.028). Conclusions: Results of this pilot study suggest that similar short-term improvements can be achieved with one BT treatment guided by <superscript>129</superscript> Xe MRI when compared with standard three-treatment-session BT with fewer periprocedure adverse events.
- Subjects :
- Adult
Bronchial Thermoplasty adverse effects
Double-Blind Method
Female
Humans
Male
Middle Aged
Pilot Projects
Quality of Life
Severity of Illness Index
Treatment Outcome
Asthma surgery
Bronchial Thermoplasty methods
Magnetic Resonance Imaging methods
Surgery, Computer-Assisted
Xenon Isotopes therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1535-4970
- Volume :
- 202
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- American journal of respiratory and critical care medicine
- Publication Type :
- Academic Journal
- Accession number :
- 32510976
- Full Text :
- https://doi.org/10.1164/rccm.201905-1021OC