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Jackhammer esophagus: Clinical presentation, manometric diagnosis, and therapeutic results-Results from a multicenter French cohort.
- Source :
-
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society [Neurogastroenterol Motil] 2020 Nov; Vol. 32 (11), pp. e13918. Date of Electronic Publication: 2020 Jun 08. - Publication Year :
- 2020
-
Abstract
- Background/aims: Jackhammer esophagus (JE) is a hypercontractile esophageal motor disorder defined by at least two swallows with a distal contractile integral (DCI) >8000 mm Hg.s.cm during high-resolution manometry (HRM). The relationship between symptoms and hypercontractility and the response to therapies have been poorly evaluated. The aim of this study was to determine the clinical presentation, manometric diagnosis, and therapeutic results in a large cohort of JE patients.<br />Methods: Patients with JE diagnosed among the HRM tests performed in nine academic French centers from 01/01/2010 to 08/31/2016 were included. Patient charts were reviewed to collect clinical and therapeutic data.<br />Results: Among the 16 264 HRM tests performed during this period, 227 patients (60.8 ± 13.8 years, 151 male) had JE (1.7%). Dysphagia was the most frequent symptom (74.6%), followed by regurgitation (37.1%) and chest pain (36.6%); 4.7% of the patients were asymptomatic. The diagnostic workup was heterogeneous, and only a minority of patients had esophageal biopsies. None of the individual symptoms were significantly associated with any of the manometric parameters defined, except for dysphagia, which was significantly associated with the mean of all DCIs >8000 mm Hg.s.cm (P = .04). Additionally, the number of symptoms was not associated with any manometric parameter. Medical treatment and endoscopic treatments had poor efficacy and a high relapse rate.<br />Conclusion: Jackhammer esophagus is a rare motility disorder. Diagnostic workup is heterogeneous and should be standardized. Symptoms are poorly associated with manometric parameters. The medical treatments and endoscopic therapies currently used are inefficient.<br /> (© 2020 John Wiley & Sons Ltd.)
- Subjects :
- Aged
Asymptomatic Diseases
Barrett Esophagus pathology
Biopsy
Botulinum Toxins, Type A therapeutic use
Calcium Channel Blockers therapeutic use
Cohort Studies
Dilatation
Endoscopy, Digestive System methods
Endosonography
Esophageal Motility Disorders diagnosis
Esophageal Motility Disorders pathology
Esophageal Motility Disorders therapy
Esophageal pH Monitoring
Esophagitis pathology
Esophagus pathology
Female
France
Humans
Male
Manometry
Middle Aged
Muscle Contraction physiology
Myotomy
Neuromuscular Agents therapeutic use
Proton Pump Inhibitors therapeutic use
Tomography, X-Ray Computed
Chest Pain physiopathology
Deglutition Disorders physiopathology
Esophageal Motility Disorders physiopathology
Laryngopharyngeal Reflux physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2982
- Volume :
- 32
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
- Publication Type :
- Academic Journal
- Accession number :
- 32510747
- Full Text :
- https://doi.org/10.1111/nmo.13918